Learn about ACL repair with the BEAR ACL repair

Glucosamine and Chondroitin for Arthritis

What's the Science Say?

Glucosamine and Chondroitin2022-06-18T16:35:13-10:00

(808)439-6201

The Queen’s Medical Center
POB 1, Suite 808
1380 Lusitana Street
Honolulu, Hawaii 96813

info@doctormorton.com

Schedule Online

Many people have heard about glucosamine and chondroitin for osteoarthritis treatment. But are they effective at relieving pain and stiffness? Read more to find out.

Osteoarthritis and the associated symptoms can be debilitating. While there are many treatments to choose from, many are ineffective. Chondroitin and glucosamine is a popular supplement that boasts to relieve joint pain. However, the research is actually more mixed than popularly reported. It is essential to understand the research glucosamine and chondroitin to better understand how effective it is.

Glucosamine

What is Glucosamine and Chondroitin?

Glucosamine and chondroitin, often referred to as chondroitin sulfate, are naturally occurring compounds found in the body. Chondroitin is usually found in cartilage around joints but can also be made in the lab. It can be taken by mouth for osteoarthritis or used as eye drops for dry eyes and cataract surgery.

Glucosamine is another compound naturally found in cartilage. It can also be harvested from shells of shellfish or made in the lab. It can also be taken orally and has been implicated in the treatment of arthritis.

Research on Glucosamine and Chondroitin

Osteoarthritis is caused by overuse, which in turn causes degenerative changes in the bone and cartilage of the joint. Current treatment consists of non-steroidal anti-inflammatory drugs (NSAIDs) and supportive rehabilitation, like exercise. While these medications are over the counter, they are not without their risks. Newer research has focused on medications with lower risk profiles, called symptomatic slow-acting drugs (SYSADOAs). Glucosamine and chondroitin are SYSADOAs.

Glucosamine and chondroitin are naturally occurring compounds in the body. Theoretically, they are thought to be absorbed by the body and then traverse to the joints. They are considered to slow the rate of degeneration in the joint. However, different studies have conflicted as to their actual effectiveness when used for osteoarthritis.

Results of this Research

One review combined the many randomized clinical trials associated with glucosamine and chondroitin to organize and analyze the data. Overall, the researchers analyzed 7,172 participants in the meta-analysis with knee osteoarthritis. They found that glucosamine actually had no effect on pain compared to the placebo treatment. In other words, glucosamine was ineffective in relieving pain. However, it was slightly effective in reducing stiffness.

Chondroitin was more effective in reducing pain than the placebo drug. However, it was not effective in reducing stiffness. Additionally, glucosamine, in combination with chondroitin, also showed no effect compared to placebo treatment in regards to pain scores.

Overall, the researchers in this study concluded that oral chondroitin was more effective in relieving pain than the placebo. Glucosamine, on the other hand, was not more effective at pain relief and only marginally better at relieving stiffness. They concluded that they needed further studies on glucosamine and chondroitin combination therapy to better assess its effectiveness in the treatment of osteoarthritis.

Summary

Glucosamine and chondroitin are only slightly effective for osteoarthritis symptoms. Glucosamine is somewhat more effective at reducing stiffness than the placebo treatment, and chondroitin is more effective at reducing pain. Still, the Osteoarthritis Research Society International guidelines have not included it in the treatment parameters. Currently, there is not enough evidence for physician societies to definitively recommend either of these treatments.

Frequently Asked Questions about Glucosamine and Chondroitin

How much do glucosamine and chondroitin cost?2021-02-27T20:55:25-10:00

The cost of these medications depends on the brand and the number of pills. Tablets containing both glucosamine and chondroitin can be found for around $16 for 150 tablets. Chondroitin can be found on its own for about $15 for 120 pills. Glucosamine can be found for about $13 for 150 capsules. It is important to note that vitamins and supplements are not regulated by a government body to ensure their purity and efficacy. This means that these pills may not always be reliable or may not contain a high enough dosage to make a difference.

What are the current nonoperative treatment guidelines for osteoarthritis?2021-02-27T20:55:07-10:00

Physicians recommend the combination of exercise, weight loss, self-management programs, tai chi, cane use, topical NSAIDs, and glucocorticoid injections. They also state that some people may benefit from balance exercises and cognitive behavioral therapy.

Are glucosamine and chondroitin harmful?2021-02-27T20:54:46-10:00

Generally, glucosamine is safe and well-tolerated. There is a risk of an allergic reaction. Common side effects include nausea, vomiting, abdominal pain, and diarrhea. Chondroitin has also been shown to be safe. Like glucosamine, chondroitin is also associated with stomach pain, nausea, and diarrhea. It has also been associated with headaches and irregular heartbeat.

Why does cold weather make my hip or knee pain worse?2021-02-27T20:51:43-10:00

Weather changes cause a change in barometric pressure. Cold and damp weather can cause your joint to feel swollen and painful. Many patients who move from colder climates feel an improvement in their hip or knee pain.

What causes an arthritis flare or trigger?2021-02-27T20:51:22-10:00

Arthritis can be triggered by increased stress across the joint such as trauma, overdoing your normal activities, cold weather, elevated weight, or repetitive motions.

Does exercise help arthritis?2021-02-27T20:51:06-10:00

Exercise is a great way to help build strength and flexibility around a painful hip or knee joint. Building strength takes pressure off your joint and reduces your pain levels. Physical therapy and exercise are some of the best non-operative treatments for arthritis.

What is the most effective treatment for hip or knee arthritis? Can you make arthritis go away?2021-02-27T20:50:45-10:00

While injections, medications, and small procedures have been able to help with temporary relief of pain, the most effective treatment is a hip or knee replacements. For many patients, joint replacements are able to provide long-lasting pain relief and help them return to normal.

Can hip or knee arthritis be cured permanently?2021-02-27T20:50:24-10:00

Science has been looking for a cure for arthritis for a long time. At this point, we have very good treatments that alleviate pain and inflammation. Nonoperative treatment for arthritis helps people stay active with their normal knees for a longer time, sometimes avoiding surgery altogether. There are excellent surgical treatments available to help with arthritis.

By /Published On: December 21, 2020/Last Updated: June 18, 2022/3 min read/

Schedule an Appointment

Meet Dr. Paul Norio Morton

Dr. Paul Norio Morton, MD, FAAOS, FAAHKS is a board-certified, fellowship-trained orthopedic surgeon in hip and knee surgery, specializing in robotic joint replacements, complex joint reconstruction, sports injuries, and trauma. He practices orthopedic surgery inHonolulu, West Oahu, and Kailua-Kona on the Big Island. Reach out to him to learn more about treatment options for your problem.

Dr. Morton with a Tablet

Dr. Paul N. Morton created and maintains this website as a service to his patients and to our community. This website is part of his mission to become one of the best orthopedic doctors in Hawaii. Dr. Morton maintains the site content and strives to keep it fresh. He makes no warranty or guarantee regarding content accuracy.

While most of the information discussed on jointreplacementhawaii.com or doctormorton.com and patients should not construe the information as medical advice. Please refer all questions in regards to your health or health conditions to your physician. While there may be links to other sites, Dr. Morton does not endorse the linked sites and takes no responsibility for the content or information contained in the linked sites.

Some of the content obtained on this website are listed under the licenses page. Please view this page for further information.

Otherwise, the content found on this website is owned by Dr. Paul Morton. All rights reserved. No part of this website may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from Dr. Morton.

The Queen’s Medical Center
Physician Office Building 1
Suite 808
1380 Lusitana Street
Honolulu, Hawaii 96813
USA

info@doctormorton.com

+1(808) 439-6201

© 2023 Paul N. Morton, MD.

Licenses

Privacy Policy

Disclaimer

Good Faith Estimate

Surprise Medical Bills

Take Control of Your Bone and Joint Health With Dr. Morton
Type your Full Name
Need at least 6 numbers. Use numbers only.
Talk with Dr. Morton here

By submitting this form, you consent to receive marketing emails from Paul Morton, MD, 1380 Lusitana Street, Suite 808, Honolulu, HI 96813, https://www.doctormorton.com/. You can revoke your consent to receive emails at any time by using the SafeUnsubscrube® link, found at the bottom of every email. Emails are serviced by Constant Contact.

Tell us about yourself

We look forward to serving you.

First Name
Last Name
Email Address
Phone Number

Request a Quote

We support pricing transparency.

How can we help you?
Location
Additional Information

I have read and accept the terms & privacy. By submitting this form, you consent to receive marketing emails from Paul Morton, MD, 1380 Lusitana Street, Suite 808, Honolulu, HI 96813, https://www.doctormorton.com/. You can revoke your consent to receive emails at any time by using the SafeUnsubscrube® link, found at the bottom of every email. Emails are serviced by Constant Contact.